FOXO4 antibodies are essential tools in studying the Forkhead box O (FOXO) family of transcription factors, which regulate cellular processes like apoptosis, stress resistance, and metabolism. FOXO4. a key member, is implicated in aging, cancer, and oxidative stress responses. It functions as a tumor suppressor by activating genes that control cell cycle arrest or death. Its activity is tightly regulated by post-translational modifications (e.g., phosphorylation, acetylation) and nucleocytoplasmic shuttling, often mediated by pathways like PI3K/AKT. Dysregulation of FOXO4 is linked to age-related diseases, cancer progression, and metabolic disorders.
FOXO4-specific antibodies enable researchers to detect protein expression, localization, and modifications in cells or tissues. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study FOXO4's role in cellular senescence, DNA repair, and interactions with other proteins (e.g., p53). Recent studies highlight FOXO4's involvement in modulating autophagy and mitigating oxidative damage, making its antibodies critical in aging research and therapeutic development. Validated antibodies with high specificity (confirmed via knockout/knockdown controls) are crucial for ensuring reliable experimental outcomes, particularly in exploring FOXO4-targeted therapies for age-related diseases or cancer.