B4GAT1抗体,Rabbit Polyclonal B4GAT1 Antibody
  • B4GAT1抗体,Rabbit Polyclonal B4GAT1 Antibody
  • B4GAT1抗体,Rabbit Polyclonal B4GAT1 Antibody
  • B4GAT1抗体,Rabbit Polyclonal B4GAT1 Antibody

B4GAT1抗体;B4GAT1 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-27
QQ交谈 微信洽谈

产品详情

中文名称:B4GAT1抗体英文名称:Rabbit Polyclonal B4GAT1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6949 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: B4GAT1
2025-05-27 B4GAT1抗体 Rabbit Polyclonal B4GAT1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6949 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesiGAT; iGNT; B3GNT1; B3GNT6; B3GN-T1; MDDGA13; BETA3GNTI
WB Predicted band size47 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human B4GAT1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P12935(B4GAT1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12935(B4GAT1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于B4GAT1抗体的3-4篇文献示例(注:文献信息为模拟概括,具体引用需核实真实数据库):

1. **文献名称**:*"Defective glycosylation of α-dystroglycan contributes to neuromuscular pathology in B4GAT1-mutated mice"*

**作者**:Yoshida-Moriguchi T, Campbell KP

**摘要**:研究利用B4GAT1抗体分析基因突变小鼠模型中α-dystroglycan的异常糖基化,揭示其与先天性肌营养不良症的关联,抗体用于Western blot和免疫组化验证蛋白表达缺失。

2. **文献名称**:*"B4GAT1 is a key regulator of glycosaminoglycan synthesis in human cells"*

**作者**:Praissman JL et al.

**摘要**:通过B4GAT1抗体抑制实验,证明该酶在糖胺聚糖合成中的核心作用,抗体被用于流式细胞术检测细胞表面糖基化水平变化。

3. **文献名称**:*"Antibody-based profiling of B4GAT1 in cancer: Implications for tumor metastasis"*

**作者**:Zhang Y et al.

**摘要**:使用B4GAT1抗体对多种癌症组织进行免疫染色,发现其高表达与肿瘤转移相关,提示其作为潜在治疗靶点。

4. **文献名称**:*"A comprehensive review on the role of B4GAT1 in congenital disorders of glycosylation"*

**作者**:Wells L

**摘要**:综述B4GAT1在糖基化疾病中的功能,总结抗体在诊断和机制研究中的应用,包括患者细胞系中蛋白定位分析。

**注意**:以上文献信息为示例性质,实际文献需通过PubMed、Google Scholar等平台以“B4GAT1 antibody”为关键词检索确认。

       

背景信息

B4GAT1 (Beta-1.4-galactosyltransferase 1) is an enzyme encoded by the B4GAT1 gene, which plays a critical role in glycosylation processes. It catalyzes the transfer of galactose to terminal N-acetylglucosamine residues in glycoproteins and glycolipids, contributing to the synthesis of poly-N-acetyllactosamine chains—a key component of extracellular matrix structures. B4GAT1 is part of the glycosyltransferase 7 family and is notably involved in the post-translational modification of alpha-dystroglycan (α-DG), a protein essential for maintaining muscle membrane integrity and neuronal development. Dysregulation of B4GAT1-mediated glycosylation is linked to congenital disorders of glycosylation (CDGs), particularly Walker-Warburg syndrome and muscle-eye-brain disease, characterized by severe muscular dystrophy, brain malformations, and ocular defects.

Antibodies targeting B4GAT1 are vital tools for studying its expression, localization, and function in both normal and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cell lines. Research utilizing B4GAT1 antibodies has advanced understanding of glycosylation defects in neuromuscular diseases and helped identify biomarkers for diagnostics. Additionally, these antibodies aid in exploring therapeutic strategies aimed at restoring glycosylation pathways. Commercial B4GAT1 antibodies are typically raised in rabbits or mice, with validation steps confirming specificity for human, mouse, or rat isoforms. Ongoing studies continue to refine their applications in mechanistic and translational research.

       
关键字: B4GAT1抗体;B4GAT1;B4GAT1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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