The NIBAN3 antibody is designed to target the NIBAN3 protein, encoded by the *FAM129B* gene, which belongs to the FAM129 family implicated in cellular stress responses and cancer progression. NIBAN3 is a less-characterized member compared to its homologs (e.g., NIBAN1/FAM129A), though emerging studies suggest its involvement in regulating apoptosis, autophagy, and cell survival under stress conditions. It is hypothesized to interact with signaling pathways like mTOR or ER stress cascades, influencing cellular adaptation to metabolic or environmental challenges. Dysregulation of NIBAN3 has been loosely associated with tumorigenesis, particularly in cancers where stress tolerance mechanisms are hijacked. The NIBAN3 antibody, typically developed in rabbit or mouse models, serves as a critical tool for detecting endogenous NIBAN3 protein levels via techniques such as Western blotting, immunohistochemistry, or immunofluorescence. Its specificity is validated using knockout controls to ensure accurate detection in research models. Current applications focus on elucidating NIBAN3's role in disease contexts, including cancer biology and neurodegenerative disorders linked to protein misfolding. Further studies using this antibody aim to clarify its molecular interactions and therapeutic potential, bridging gaps in understanding stress-responsive pathways in health and disease.