The AGAP3 (ArfGAP with GTPase domain, Ankyrin repeat and PH domain 3) antibody is a research tool used to study the AGAP3 protein, a member of the ARFGAP family involved in regulating ADP-ribosylation factors (ARFs). These small GTPases play critical roles in membrane trafficking, cytoskeletal organization, and cellular signaling. AGAP3 contains multiple functional domains, including a GTPase-activating protein (GAP) domain that inactivates ARFs by promoting GTP hydrolysis, an ankyrin repeat region for protein interactions, and a pleckstrin homology (PH) domain for membrane localization. AGAP3 is implicated in neuronal development, synaptic plasticity, and receptor trafficking, particularly in glutamate receptor regulation. Dysregulation of AGAP3 has been linked to neurological disorders, such as autism spectrum disorders, and cancer progression due to its role in cell migration and invasion. Researchers use AGAP3 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression, localization, and interactions in cellular and disease models. These antibodies aid in elucidating AGAP3's molecular mechanisms and potential therapeutic targets in associated pathologies.