The CORO1B antibody is a crucial tool for studying coronin-1B (CORO1B), a member of the coronin protein family involved in regulating actin cytoskeleton dynamics. Coronins are evolutionarily conserved proteins that play roles in cell migration, membrane trafficking, and immune responses. CORO1B, specifically, is ubiquitously expressed and interacts with actin filaments and Arp2/3 complexes to modulate actin polymerization, branching, and network remodeling. It also participates in signaling pathways linked to cell motility, vesicle trafficking, and phagocytosis. Dysregulation of CORO1B has been associated with cancer metastasis, neurological disorders, and immune dysfunctions, making it a target for biomedical research.
The CORO1B antibody enables detection and quantification of CORO1B protein levels in various experimental setups, including Western blotting, immunofluorescence, and immunohistochemistry. Researchers use it to investigate CORO1B's subcellular localization, interaction partners, and expression patterns under physiological or pathological conditions. Its specificity and reliability are critical for elucidating CORO1B's role in diseases like glioblastoma, breast cancer, and autoimmune disorders. Commercially available CORO1B antibodies are typically raised in hosts like rabbits or mice, with validation across multiple applications. Ongoing studies leveraging this antibody continue to uncover CORO1B's mechanistic contributions to cellular processes, offering potential therapeutic insights.