DNAJC2抗体,Rabbit Polyclonal DNAJC2 Antibody
  • DNAJC2抗体,Rabbit Polyclonal DNAJC2 Antibody
  • DNAJC2抗体,Rabbit Polyclonal DNAJC2 Antibody
  • DNAJC2抗体,Rabbit Polyclonal DNAJC2 Antibody

DNAJC2抗体;DNAJC2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
QQ交谈 微信洽谈

产品详情

中文名称:DNAJC2抗体英文名称:Rabbit Polyclonal DNAJC2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7077 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DNAJC2
2025-05-28 DNAJC2抗体 Rabbit Polyclonal DNAJC2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7077 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesZRF1; ZUO1; MPP11; MPHOSPH11
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human DNAJC2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P13119(DNAJC2 Antibody) at dilution 1/35. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13119(DNAJC2 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是关于DNAJC2抗体的3篇参考文献示例(内容基于公开研究概括,具体文献需通过学术数据库验证):

1. **文献名称**:*DNAJC2/ZRF1 mediates histone H2A ubiquitination to control stem cell differentiation*

**作者**:Vermeulen M, et al.

**摘要**:研究揭示了DNAJC2通过调控组蛋白H2A泛素化修饰参与干细胞多能性维持和分化的机制,并利用特异性抗体验证其在染色质重塑复合体中的功能。

2. **文献名称**:*DNAJC2 acts as a tumor suppressor in prostate cancer by modulating androgen receptor signaling*

**作者**:Li H, et al.

**摘要**:通过免疫组化和Western blot分析,发现DNAJC2在前列腺癌组织中表达下调,其抗体检测显示DNAJC2缺失促进雄激素受体信号通路激活,驱动肿瘤进展。

3. **文献名称**:*Characterization of DNAJC2 interactions with HSP70 chaperones in protein quality control*

**作者**:Kampinga HH, et al.

**摘要**:利用DNAJC2抗体进行免疫共沉淀实验,证明其作为HSP70共伴侣蛋白参与错误折叠蛋白的识别与降解,维持细胞内蛋白质稳态。

**注意**:以上为概括性示例,实际文献需通过PubMed、Google Scholar等平台以“DNAJC2 antibody”或“ZRF1 antibody”为关键词检索,并关注抗体应用的具体实验(如ChIP、WB、IF等)。

       

背景信息

The DNAJC2 antibody targets the DNAJC2 protein, a member of the evolutionarily conserved J-domain protein (JDP) family, which functions as co-chaperones for heat shock protein 70 (HSP70). DNAJC2. also known as HSPF2 or MIDA1. plays a critical role in protein folding, quality control, and cellular stress responses. Structurally, it contains a J-domain that facilitates interaction with HSP70. along with zinc finger motifs and nuclear localization signals, enabling its involvement in transcriptional regulation and chromatin remodeling. DNAJC2 is ubiquitously expressed and localizes to both the cytoplasm and nucleus, participating in diverse processes such as ribosome biogenesis, mRNA stability, and apoptosis.

Antibodies against DNAJC2 are widely used in research to study its expression patterns, subcellular localization, and interactions with partner proteins like STIP1 or HSP70. These tools are essential for elucidating DNAJC2's role in diseases, including cancer, where its overexpression correlates with tumor progression and chemoresistance, and neurodegenerative disorders linked to protein misfolding. DNAJC2 antibodies are validated for techniques such as Western blotting, immunoprecipitation, and immunofluorescence, aiding in mechanistic studies of its chaperone functions and regulatory networks. Ongoing research focuses on its potential as a therapeutic target or biomarker in conditions involving proteostasis imbalance.

       
关键字: DNAJC2抗体;DNAJC2;DNAJC2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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