The DBX2 antibody is a research tool designed to detect DBX2 (Developing Brain Homeobox 2), a transcription factor containing a homeodomain that plays critical roles in neural development. DBX2 is part of the DBX family, which regulates the differentiation of progenitor cells in the developing central nervous system, particularly in the spinal cord and brain. It is involved in specifying the fate of neural precursor cells, influencing the formation of inhibitory and excitatory interneurons, and contributing to the establishment of neural circuitry. Dysregulation of DBX2 has been linked to developmental disorders and neurodegenerative conditions.
The DBX2 antibody is widely used in neuroscience and developmental biology research to study protein expression patterns, localization, and function in vitro and in vivo. It enables techniques such as Western blotting, immunohistochemistry, and immunofluorescence to visualize DBX2 in tissue sections or cultured cells. Researchers utilize this antibody to explore mechanisms of neural differentiation, spinal cord development, and potential roles in diseases like cancer, where DBX2 may act as a tumor suppressor or oncogene depending on context.
Validated for specificity and sensitivity, DBX2 antibodies are typically raised in hosts like rabbits or mice, targeting conserved epitopes across species. Their application advances understanding of developmental pathways and disease mechanisms, offering insights for therapeutic targeting.