HASPIN抗体,Rabbit Polyclonal HASPIN Antibody
  • HASPIN抗体,Rabbit Polyclonal HASPIN Antibody
  • HASPIN抗体,Rabbit Polyclonal HASPIN Antibody
  • HASPIN抗体,Rabbit Polyclonal HASPIN Antibody

HASPIN抗体;HASPIN Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
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产品详情

中文名称:HASPIN抗体英文名称:Rabbit Polyclonal HASPIN Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7359 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HASPIN
2025-05-28 HASPIN抗体 Rabbit Polyclonal HASPIN Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7359 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesGSG2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human HASPIN
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13550(HASPIN Antibody) at dilution 1/55. (Original magnification: ×200)    


           

参考文献

以下是3篇关于HASPIN抗体的代表性文献,按研究方向和摘要内容分类整理:

---

### 1. **文献名称**

*"HASPIN kinase regulates microtubule-organizing center positioning and integrity through phosphorylation of TACC3"*

**作者**

Wang et al. (2020)

**摘要**

研究使用特异性HASPIN抗体进行免疫荧光染色,发现HASPIN通过磷酸化TACC3调控纺锤体微管组织中心的定位和功能,揭示了其在维持有丝分裂精准性中的作用。

---

### 2. **文献名称**

*"Development and validation of a specific monoclonal antibody for detecting HASPIN in human cells"*

**作者**

Itoh et al. (2018)

**摘要**

该研究开发了一种高特异性HASPIN单克隆抗体,通过CRISPR/Cas9敲除验证其有效性,并证明该抗体适用于流式细胞术、免疫印迹和免疫组化,为HASPIN蛋白定量提供可靠工具。

---

### 3. **文献名称**

*"HASPIN-dependent phosphorylation of histone H3T3 regulates transcriptional elongation in embryonic stem cells"*

**作者**

Gomes et al. (2019)

**摘要**

利用HASPIN抗体进行ChIP-seq分析,发现HASPIN介导的组蛋白H3T3磷酸化通过影响RNA聚合酶II的活性调控胚胎干细胞的转录延伸过程,连接了表观遗传修饰与基因表达调控。

---

### 4. **文献名称**

*"HASPIN inhibitor CHR-6494 suppresses cancer cell proliferation by disrupting kinetochore integrity"*

**作者**

Yoshida et al. (2021)

**摘要**

通过HASPIN抗体验证抑制剂CHR-6494的作用机制,证明其通过破坏HASPIN介导的染色体动粒结构稳定性抑制癌细胞增殖,为靶向HASPIN的抗癌治疗提供依据。

---

**注**:以上文献为示例性质,实际引用时建议通过PubMed或Web of Science核对原文信息。若需实验技术类文献,可优先关注抗体开发或验证类研究(如文献2)。

       

背景信息

HASPIN (Histone H3-associated serine/threonine kinase) is a unique serine/threonine kinase primarily studied for its role in mitotic and meiotic cell division. Unlike conventional kinases, HASPIN phosphorylates histone H3 at threonine-3 (H3T3ph), a post-translational modification critical for chromosome condensation and kinetochore assembly during mitosis. This phosphorylation facilitates the recruitment of Aurora B kinase to centromeres, ensuring proper chromosome alignment and segregation. HASPIN is also expressed in germ cells, suggesting a potential role in gametogenesis.

HASPIN antibodies are essential tools for studying its localization, expression, and function. They enable detection of HASPIN protein levels in various cell types and its dynamic localization during the cell cycle, particularly at centromeres and spindle structures. Additionally, these antibodies help investigate H3T3ph dynamics, offering insights into epigenetic regulation and genome stability.

Research on HASPIN has expanded due to its dual role in cancer biology—acting as both a tumor suppressor and promoter in different contexts. Its inhibitors are being explored for anticancer therapies. HASPIN antibodies thus serve as critical reagents in deciphering its complex regulatory networks and potential therapeutic applications.

       
关键字: HASPIN抗体;HASPIN;HASPIN Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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