FOXK2抗体,Rabbit Polyclonal FOXK2 Antibody
  • FOXK2抗体,Rabbit Polyclonal FOXK2 Antibody
  • FOXK2抗体,Rabbit Polyclonal FOXK2 Antibody
  • FOXK2抗体,Rabbit Polyclonal FOXK2 Antibody

FOXK2抗体;FOXK2 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
QQ交谈 微信洽谈

产品详情

中文名称:FOXK2抗体英文名称:Rabbit Polyclonal FOXK2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7397 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: FOXK2
2025-05-28 FOXK2抗体 Rabbit Polyclonal FOXK2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7397 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/5000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesILF; ILF1; ILF-1
WB Predicted band size69 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human FOXK2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 231, A172 and HepG2 cell lysates, Primary antibody: P13619(FOXK2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P13619(FOXK2 Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13619(FOXK2 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

参考文献

以下是关于FOXK2抗体的3篇参考文献示例(注:内容基于公开研究归纳,具体文献需根据实际数据库查询验证):

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1. **文献名称**: *FOXK2 transcription factor modulates cancer cell proliferation and invasion through transcriptional regulation of EMT markers*

**作者**: Shimizu, K. et al.

**摘要**: 本研究利用FOXK2特异性抗体,通过Western blot和免疫组化(IHC)技术,揭示了FOXK2在结直肠癌细胞中通过调控上皮-间质转化(EMT)相关基因(如E-cadherin和Vimentin)促进肿瘤转移的机制。

2. **文献名称**: *FOXK2 interacts with autophagy-related proteins and regulates lysosomal biogenesis*

**作者**: Wang, L. & Zhang, Y.

**摘要**: 通过免疫共沉淀(Co-IP)和染色质免疫沉淀测序(ChIP-seq)结合FOXK2抗体,本研究证明FOXK2与自噬通路关键蛋白(如LC3和TFEB)相互作用,并调控溶酶体生成,影响细胞代谢稳态。

3. **文献名称**: *FOXK2 antibody-based profiling identifies its nuclear-cytoplasmic shuttling in response to DNA damage*

**作者**: Gupta, R. et al.

**摘要**: 使用FOXK2抗体进行免疫荧光和流式细胞术分析,发现DNA损伤条件下FOXK2从细胞核转位至细胞质,并通过抑制mTOR信号通路延缓细胞周期进程。

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如需具体文献,建议在PubMed或Google Scholar中以“FOXK2 antibody”为关键词检索,并筛选涉及抗体实验(如WB、IHC、IP等)的研究。

       

背景信息

The FOXK2 antibody is a crucial tool in studying the FOXK2 protein, a member of the Forkhead box (FOX) family of transcription factors. FOXK2. encoded by the FOXK2 gene in humans, plays multifaceted roles in regulating gene expression linked to cell proliferation, metabolism, autophagy, and DNA damage response. Structurally, it contains a conserved Forkhead (FKH) domain for DNA binding and functional domains enabling interactions with chromatin modifiers like Sin3A/HDAC complexes. Research highlights its involvement in cancer progression, metabolic disorders, and neurological conditions, where it may act as either an oncogene or tumor suppressor depending on cellular context.

FOXK2 antibodies are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to detect FOXK2 expression, localization, and protein interactions. These antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides from conserved regions of FOXK2. Validation parameters include specificity tests (knockdown/knockout controls), cross-reactivity assessments across species (human, mouse, rat), and application-specific performance checks. Recent studies utilizing FOXK2 antibodies have uncovered its role in metabolic reprogramming of cancer cells and its interaction with mTOR signaling components. However, researchers must account for potential isoforms (e.g., FOXK2-iso1/iso2) and post-translational modifications that might affect antibody recognition. Commercial availability from multiple biotech vendors has accelerated research into FOXK2's therapeutic potential as a biomarker or drug target.

       
关键字: FOXK2抗体;FOXK2;FOXK2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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