FERMT1抗体,Rabbit Polyclonal FERMT1 Antibody
  • FERMT1抗体,Rabbit Polyclonal FERMT1 Antibody
  • FERMT1抗体,Rabbit Polyclonal FERMT1 Antibody
  • FERMT1抗体,Rabbit Polyclonal FERMT1 Antibody

FERMT1抗体;FERMT1 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
QQ交谈 微信洽谈

产品详情

中文名称:FERMT1抗体英文名称:Rabbit Polyclonal FERMT1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7461 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: FERMT1
2025-05-28 FERMT1抗体 Rabbit Polyclonal FERMT1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7461 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesURP1; KIND1; DTGCU2; UNC112A; C20orf42
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human FERMT1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13736(FERMT1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是3篇与FERMT1抗体相关的文献摘要信息:

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1. **文献名称**: *Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk1*

**作者**: Sun et al. (2015)

**摘要**: 该研究使用FERMT1(Kindlin-1)抗体进行免疫共沉淀和免疫荧光实验,发现Kindlin-1通过整合素和Polo样激酶1(Plk1)调控有丝分裂纺锤体形成,影响细胞周期进程和癌症细胞增殖。

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2. **文献名称**: *FERMT1 promotes tumor progression and metastasis in colorectal cancer via regulating EGFR signaling*

**作者**: Zhang et al. (2018)

**摘要**: 作者通过Western blot和免疫组化(使用FERMT1抗体)证实FERMT1在结直肠癌中高表达,并揭示其通过激活EGFR信号通路促进肿瘤侵袭和转移的分子机制。

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3. **文献名称**: *Loss of Kindlin-1 in keratinocytes impairs epidermal adhesion and leads to modified inflammatory response*

**作者**: Herz et al. (2020)

**摘要**: 研究利用FERMT1抗体在皮肤组织样本中进行染色,发现Kindlin-1缺失导致角质细胞粘附功能异常,并改变炎症反应,为Kindler综合征(一种遗传性皮肤疾病)的病理机制提供新见解。

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以上文献均通过FERMT1抗体探究其在癌症、细胞周期或遗传病中的功能。如需具体DOI或期刊信息可进一步补充。

       

背景信息

FERMT1. also known as Kindlin-1. is a protein encoded by the FERMT1 gene and belongs to the kindlin family of focal adhesion proteins. It plays a critical role in cell-matrix adhesion, integrin activation, and cellular signaling by connecting the cytoskeleton to extracellular matrix components. Structurally, it contains a FERM domain (F0-F3 subdomains) that mediates interactions with integrin β subunits and other cytoskeletal proteins. Dysregulation of FERMT1 is linked to several pathologies, including Kindler epidermolysis bullosa, a rare autosomal recessive skin disorder characterized by skin fragility, photosensitivity, and increased cancer risk due to loss-of-function mutations.

FERMT1 antibodies are essential tools for studying the protein's expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect FERMT1 in tissues or cultured cells. Researchers employ them to investigate mechanisms underlying epithelial integrity, wound healing, and cancer progression, as FERMT1 overexpression has been implicated in tumor metastasis and drug resistance in certain cancers. Additionally, FERMT1 antibodies aid in diagnosing genetic disorders like Kindler syndrome by identifying protein deficiencies in patient samples. Their specificity and validation across species make them valuable for translational research aiming to develop targeted therapies for FERMT1-related diseases.

       
关键字: FERMT1抗体;FERMT1;FERMT1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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