FetuinB抗体;FetuinB Antibody—艾普蒂 新品

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     Western blot analysis of Fetuin B expression in human serum cell lysate.    

  
  

**Background of FetuinB Antibody**

FetuinB, a liver-secreted glycoprotein belonging to the cystatin superfamily, shares structural homology with Fetuin-A but exhibits distinct functional roles. Primarily expressed in the liver and reproductive tissues, FetuinB is implicated in regulating protease activity, mineralization processes, and metabolic pathways. Studies highlight its critical role in fertilization by modulating zona pellucida hardening, preventing polyspermy. Dysregulation of FetuinB is associated with metabolic disorders (e.g., insulin resistance, non-alcoholic fatty liver disease), reproductive abnormalities, and certain cancers.

FetuinB antibodies are essential tools for detecting and quantifying FetuinB in research and diagnostics. Polyclonal or monoclonal antibodies target specific epitopes, enabling applications in Western blotting, ELISA, immunohistochemistry, and functional studies to explore FetuinB's mechanisms. Neutralizing antibodies further help dissect its role in protease inhibition or signaling pathways. Recent interest in FetuinB stems from its potential as a biomarker for metabolic syndrome or ovarian dysfunction, as well as therapeutic targeting in conditions like infertility or liver fibrosis. However, its pleiotropic functions and tissue-specific expression necessitate rigorous validation of antibody specificity to avoid cross-reactivity with homologous proteins like Fetuin-A. Ongoing research aims to clarify its dual roles in health and disease, positioning FetuinB antibodies as pivotal reagents in translational and mechanistic studies.