NOX2/CYBB/gp91phox抗体,Rabbit Monoclonal NOX2/CYBB/gp91phox Antibody
  • NOX2/CYBB/gp91phox抗体,Rabbit Monoclonal NOX2/CYBB/gp91phox Antibody
  • NOX2/CYBB/gp91phox抗体,Rabbit Monoclonal NOX2/CYBB/gp91phox Antibody
  • NOX2/CYBB/gp91phox抗体,Rabbit Monoclonal NOX2/CYBB/gp91phox Antibody

NOX2/CYBB/gp91phox抗体;NOX2/CYBB/gp91phox Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-29
QQ交谈 微信洽谈

产品详情

中文名称:NOX2/CYBB/gp91phox抗体英文名称:Rabbit Monoclonal NOX2/CYBB/gp91phox Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7937 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: NOX2/CYBB/gp91phox
2025-05-29 NOX2/CYBB/gp91phox抗体 Rabbit Monoclonal NOX2/CYBB/gp91phox Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7937 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesCGD; CGD91-phox; Cytochrome b-245 heavy chain; CGD91-phox; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide;;NOX2
WB Predicted band size65 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human NOX2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

  •  

     

       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


  •  

     

       Western blot analysis of NOX2/CYBB/gp91phox expression in MCF-7 cell lysate.    


           

参考文献

以下是3篇关于NOX2/CYBB/gp91phox抗体的代表性文献及其摘要概括:

---

1. **文献名称**: *"Defective NADPH oxidase activity in chronic granulomatous disease"*

**作者**: R. A. Clark et al.

**摘要**: 该研究首次揭示了CYBB基因编码的gp91phox蛋白在NADPH氧化酶复合体中的核心作用。通过使用特异性抗体检测患者中性粒细胞,证实gp91phox表达缺失导致活性氧(ROS)生成缺陷,从而阐明慢性肉芽肿病(CGD)的分子机制。

2. **文献名称**: *"Localization of the Nox2 subunit of NADPH oxidase in phagocytic cells"*

**作者**: M. T. Quinn et al.

**摘要**: 利用抗gp91phox抗体进行免疫荧光和电镜分析,发现NOX2主要定位于中性粒细胞和巨噬细胞的胞膜及吞噬小体膜上,揭示了其在病原体杀伤过程中通过空间特异性产生活性氧的分子机制。

3. **文献名称**: *"Role of Nox2 in endothelial dysfunction during hypertension"*

**作者**: D. Sorescu et al.

**摘要**: 通过Western blot和免疫组化检测高血压模型中血管内皮细胞的NOX2表达,发现其上调与氧化应激密切相关。使用抗体特异性敲除实验证实,NOX2衍生的ROS参与血管内皮功能失调的病理过程。

---

这些文献均通过特异性抗体研究NOX2/CYBB/gp91phox的蛋白表达、定位或功能,涵盖免疫缺陷疾病、炎症反应及心血管病理机制等领域。

       

背景信息

The NOX2/CYBB/gp91phox antibody targets a critical subunit of the NADPH oxidase complex, essential for reactive oxygen species (ROS) generation in phagocytes. Encoded by the CYBB gene (located on the X chromosome), gp91phox (also termed NOX2) is a transmembrane protein that forms the catalytic core of the phagocyte NADPH oxidase. This multi-subunit enzyme complex assembles during phagocyte activation, producing superoxide anions (O₂⁻) to eliminate pathogens—a process termed the "respiratory burst." Defects in CYBB result in X-linked chronic granulomatous disease (CGD), a primary immunodeficiency characterized by recurrent infections due to impaired microbial killing.

The gp91phox antibody is widely used in research and diagnostics to study protein expression, localization, and function. It helps identify CGD patients with CYBB mutations, assess NADPH oxidase activity in immune cells, and investigate ROS-related mechanisms in inflammatory, cardiovascular, or neurodegenerative disorders. Antibody-based techniques (e.g., Western blot, immunofluorescence, flow cytometry) enable detection of gp91phox in neutrophils, macrophages, and other cell types. Additionally, it aids in exploring NOX2's role beyond immunity, including redox signaling in cancer, angiogenesis, and tissue remodeling. Its specificity and reliability make it a key tool for dissecting oxidative stress pathways and developing therapeutic strategies targeting NADPH oxidases.

       
关键字: NOX2/CYBB/gp91phox抗体;NOX2/CYBB/gp91phox;NOX2/CYBB/gp91phox A;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

NOX2/CYBB/gp91phox抗体;NOX2/CYBB/gp91phox Antibody—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
询价
碧云天生物技术有限公司
2026-04-21
询价
湖北瑞和宁生物科技有限公司
2025-05-12
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.