Hsp22抗体;Hsp22 Antibody—艾普蒂 新品

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     Western blot analysis of HSPB8/HSP22 expression in Human fetal heart lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

The Hsp22 antibody is designed to target heat shock protein 22 (Hsp22), a member of the small heat shock protein (sHSP) family. Hsp22. also known as HSPB8. is a stress-induced chaperone protein involved in cellular proteostasis, apoptosis, and autophagy. It plays a critical role in mitigating protein aggregation, a hallmark of neurodegenerative diseases like Alzheimer’s and Parkinson’s. Hsp22 is upregulated under stress conditions, such as oxidative damage or thermal shock, to stabilize misfolded proteins and facilitate their refolding or degradation via pathways like the ubiquitin-proteasome system.

Research highlights its dual role in cancer: it can act as a tumor suppressor by promoting autophagy-dependent cell death or as an oncogene by enhancing cell survival under stress. Hsp22 antibodies are vital tools for studying these mechanisms, enabling detection and quantification of the protein in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They also aid in exploring Hsp22’s interactions with other proteins, such as BAG3. in chaperone-assisted selective autophagy.

Therapeutic interest in Hsp22 is growing, particularly in modulating its activity to treat proteinopathies or cancer. Antibodies against Hsp22 may serve as diagnostic biomarkers or therapeutic agents, though clinical applications remain under investigation. Its conserved structure (an α-crystallin domain flanked by variable N/C-termini) and stress-responsive regulation make it a focus of studies on cellular adaptation and disease pathology.