Cdc16/APC6抗体;Cdc16/APC6 Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Cdc16/APC6 expression in HepG2 cell lysate.    

  
  

The Cdc16/APC6 antibody targets a conserved subunit of the anaphase-promoting complex/cyclosome (APC/C), a critical E3 ubiquitin ligase regulating cell cycle progression. APC/C orchestrates the ubiquitination and subsequent degradation of key cell cycle regulators, such as securin and cyclin B, to ensure proper transitions between metaphase, anaphase, and mitotic exit. The APC6 subunit (Cdc16 in yeast) is a core structural component of the APC/C complex, contributing to its assembly and stability. It interacts with other subunits like APC3 (CDC27) and APC8 (CDC23) to maintain the complex's architecture and catalytic activity.

Antibodies against APC6/Cdc16 are widely used to study APC/C function, cell cycle dynamics, and mitotic errors. They enable detection of APC6 expression levels, localization, and interactions in various experimental models, including yeast, mammalian cells, and human tissues. Dysregulation of APC/C subunits, including APC6. has been linked to genomic instability, cancer, and developmental disorders. These antibodies are essential tools for investigating mechanisms underlying cell cycle checkpoints, chromosome segregation, and therapeutic targeting of APC/C-related pathologies. Common applications include Western blotting, immunoprecipitation, and immunofluorescence, often validated in species like humans, mice, and *S. cerevisiae*. Host species for these antibodies typically include rabbit or mouse, with polyclonal formats offering broad utility in diverse experimental contexts.