Claudin4抗体;Claudin4 Antibody—艾普蒂 新品

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     Western blot analysis of Claudin 4 expression in MCF7 cell lysate.    

  
  

Claudin4 (CLDN4) is a key component of tight junction complexes, belonging to the claudin family of transmembrane proteins that regulate paracellular permeability and maintain cell polarity in epithelial and endothelial tissues. It plays a critical role in forming selective barriers by controlling ion and solute transport. Dysregulation of Claudin4 expression is implicated in various pathologies, including cancer, where its overexpression is frequently observed in malignancies such as pancreatic, ovarian, and gastric cancers. This upregulation is associated with enhanced cell survival, invasion, and metastasis, making Claudin4 a potential diagnostic and prognostic biomarker.

Claudin4 antibodies are essential tools for detecting and studying the protein's expression, localization, and function. They are widely used in immunohistochemistry (IHC), Western blotting, and immunofluorescence to investigate tissue-specific expression patterns or alterations in disease states. In cancer research, these antibodies help identify Claudin4 as a therapeutic target, with emerging strategies focusing on Claudin4-directed therapies (e.g., monoclonal antibodies, CAR-T cells) or Claudin4-binding toxins (e.g., CPE-based agents). Additionally, Claudin4 antibodies contribute to understanding barrier dysfunction in inflammatory bowel disease or neurological disorders. Their specificity and utility in both research and clinical settings underscore their importance in advancing studies of epithelial biology and targeted treatment development.