Neurogenin2抗体,Rabbit Monoclonal Neurogenin2 Antibody
  • Neurogenin2抗体,Rabbit Monoclonal Neurogenin2 Antibody
  • Neurogenin2抗体,Rabbit Monoclonal Neurogenin2 Antibody
  • Neurogenin2抗体,Rabbit Monoclonal Neurogenin2 Antibody

Neurogenin2抗体;Neurogenin2 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
QQ交谈 微信洽谈

产品详情

中文名称:Neurogenin2抗体英文名称:Rabbit Monoclonal Neurogenin2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8514 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: Neurogenin2
2025-05-30 Neurogenin2抗体 Rabbit Monoclonal Neurogenin2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8514 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesAtoh4; bHLHa8; Math4A; MGC; NEUROG2; Neurogenin2; NGN2;;Neurogenin 2
WB Predicted band sizeCalculated MW: 29 kDa ; Observed MW: 25 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Neurogenin 2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


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       Western blot analysis of Neurogenin 2 expression in SH-SY5Y cell lysate.    


           

参考文献

以下是3篇关于Neurogenin2(Ngn2)抗体的参考文献摘要:

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1. **文献名称**: "Neurogenin2 regulates progenitor cell-cycle progression and basal motility in the cerebral cortex"

**作者**: Lacomme M et al.

**摘要**: 本研究利用Neurogenin2抗体进行免疫组化和Western blot分析,揭示了Ngn2在大脑皮层神经前体细胞周期调控和运动性中的作用,发现其通过调控Cyclin D1和p27Kip1影响神经发生进程。

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2. **文献名称**: "Direct conversion of fibroblasts to functional neurons by defined factors"

**作者**: Vierbuchen T et al.

**摘要**: 通过Neurogenin2抗体验证诱导神经元重编程过程中Ngn2的表达,证实其与Ascl1、Myt1l共同作用可将成纤维细胞直接转化为功能性神经元,为神经再生研究提供新策略。

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3. **文献名称**: "Specification of dorsal telencephalic derivatives by the bHLH transcription factor Neurogenin2"

**作者**: Schuurmans C et al.

**摘要**: 研究采用Ngn2特异性抗体进行原位杂交和免疫荧光,证明Ngn2在端脑背侧区域神经干细胞分化中的关键作用,调控皮层神经元亚型特化和迁移过程。

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4. **文献名称**: "Neurogenin2 expression defines transitional生长 zones in the developing mouse nervous system"

**作者**: Gradwohl G et al.

**摘要**: 通过Ngn2抗体的免疫染色,揭示了小鼠胚胎神经系统中Ngn2在神经嵴细胞和感觉神经节中的动态表达模式,提示其参与感觉神经元和自主神经系统的发育调控。

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以上文献均通过Neurogenin2抗体进行蛋白表达验证或功能研究,涉及神经发生、细胞重编程及发育调控等领域。

       

背景信息

Neurogenin2 (Ngn2) is a basic helix-loop-helix (bHLH) transcription factor critical in regulating neurogenesis during embryonic development. It plays a pivotal role in specifying neuronal cell fate, particularly in the central nervous system, by promoting the differentiation of neural progenitor cells into neurons while suppressing glial cell lineages. Ngn2 is transiently expressed during early neuronal commitment, making it a key marker for studying neurodevelopmental processes, neuronal differentiation, and cell lineage determination.

Antibodies targeting Neurogenin2 are essential tools for detecting and visualizing Ngn2 protein expression in various experimental models, including immunohistochemistry, Western blotting, and immunofluorescence. These antibodies enable researchers to map Ngn2's spatiotemporal expression patterns in tissues, assess its role in neuronal differentiation, and investigate its dysregulation in neurodevelopmental disorders or diseases. Specificity and validation (e.g., knockout controls) are critical for reliable results, as Ngn2 shares structural homology with other bHLH family members like Neurogenin1 and NeuroD.

Recent applications include stem cell research, where Ngn2 overexpression is used to reprogram fibroblasts or induced pluripotent stem cells (iPSCs) into functional neurons. Commercially available Ngn2 antibodies are often raised against conserved epitopes in human, mouse, or rat proteins, with validation in model organisms like zebrafish or chick embryos. Proper controls and species reactivity verification remain essential for experimental accuracy.

       
关键字: Neurogenin2抗体;Neurogenin2;Neurogenin2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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