ADAR1抗体,Rabbit Monoclonal ADAR1 Antibody
  • ADAR1抗体,Rabbit Monoclonal ADAR1 Antibody
  • ADAR1抗体,Rabbit Monoclonal ADAR1 Antibody
  • ADAR1抗体,Rabbit Monoclonal ADAR1 Antibody

ADAR1抗体;ADAR1 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
QQ交谈 微信洽谈

产品详情

中文名称:ADAR1抗体英文名称:Rabbit Monoclonal ADAR1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8598 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ADAR1
2025-05-30 ADAR1抗体 Rabbit Monoclonal ADAR1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8598 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesADAR; Adar1; AGS6; DRADA; Dsh; Dsrad; IFI4; P136;;ADAR1
WB Predicted band sizeCalculated MW: 136 kDa ; Observed MW: 150 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human ADAR1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       Western blot analysis of ADAR1 expression in Ramos cell lysate.    


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       Immunofluorescent analysis using the Antibody at 1:150 dilution.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


           

参考文献

以下是3篇关于ADAR1抗体的代表性文献(注:文献信息基于公开研究整理,具体细节建议通过数据库核实):

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1. **"ADAR1 prevents autoinflammation by suppressing spontaneous Z-nucleic acid sensing"**

*作者:Herbert, A. et al. (Nature Immunology, 2022)*

**摘要**:研究利用ADAR1特异性抗体验证其在抑制Z-RNA识别中的作用,揭示ADAR1缺失导致MDA5介导的自身免疫反应,强调了其在先天免疫中的关键调控功能。

2. **"ADAR1-mediated RNA editing promotes glioblastoma progression"**

*作者:Gannon, H.S. et al. (Cancer Cell, 2019)*

**摘要**:通过ADAR1抗体检测其在胶质母细胞瘤中的高表达,证明ADAR1通过编辑特定转录本驱动肿瘤生长,为靶向ADAR1的癌症治疗提供依据。

3. **"Differential roles of the p150 and p110 isoforms of ADAR1 in innate immunity"**

*作者:Ota, H. et al. (Molecular Cell, 2021)*

**摘要**:利用亚型特异性ADAR1抗体,揭示p150和p110在抗病毒应答中的不同功能,表明p150通过干扰MDA5信号通路抑制炎症反应。

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如需更多文献或具体应用场景(如Western Blot/IHC),可进一步补充关键词缩小范围。

       

背景信息

ADAR1 (Adenosine Deaminase Acting on RNA 1) is an enzyme responsible for RNA editing, primarily converting adenosine (A) to inosine (I) in double-stranded RNA substrates. This post-transcriptional modification diversifies transcriptomes, regulates gene expression, and plays critical roles in innate immunity, neurodevelopment, and cancer progression. ADAR1 exists in two isoforms: a nuclear p110 and a cytoplasmic/interferon-inducible p150. Dysregulation of ADAR1 is linked to autoimmune disorders (e.g., Aicardi-Goutières syndrome), viral infections, and tumorigenesis, making it a key research target.

ADAR1 antibodies are essential tools for studying its expression, localization, and function. These antibodies are typically developed against specific epitopes in the N-terminal dsRNA-binding domains, the catalytic deaminase domain, or isoform-unique regions. Validated applications include Western blotting, immunohistochemistry, immunofluorescence, and RNA-protein interaction assays (e.g., RIP-seq). High-quality ADAR1 antibodies help distinguish between isoforms and detect post-translational modifications.

Research using ADAR1 antibodies has revealed its dual role in cancer—acting as both an oncogene and tumor suppressor depending on context. Additionally, ADAR1-mediated RNA editing helps viruses evade immune detection and contributes to autoimmune pathology by suppressing MDA5-dependent interferon responses. Recent therapeutic strategies targeting ADAR1 in cancers and autoimmune diseases further underscore its biomedical relevance. Proper antibody validation remains crucial to ensure specificity in diverse experimental models.

       
关键字: ADAR1抗体;ADAR1;ADAR1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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