Phospho-Tau(S198)抗体;Phospho-Tau(S198) Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Phospho-Tau (S198) expression in mouse hippocampus cell lysate.    

  
  

Phospho-Tau(S198) antibodies are specialized tools used to detect tau protein phosphorylated at serine residue 198. a post-translational modification implicated in neurodegenerative diseases, particularly Alzheimer’s disease (AD). Tau, a microtubule-associated protein, stabilizes neuronal cytoskeletons in normal physiology. However, hyperphosphorylation of tau disrupts its binding to microtubules, leading to aggregation into neurofibrillary tangles (NFTs), a hallmark of AD and other tauopathies. Phosphorylation at S198 is among the numerous tau modifications linked to pathological NFT formation.

Studies suggest that phosphorylation at S198 occurs early in AD progression, correlating with cognitive decline and disease severity. This site is phosphorylated by kinases such as glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinase 5 (CDK5), which are dysregulated in neurodegeneration. The Phospho-Tau(S198) antibody enables researchers to identify and quantify this specific phosphorylation event in tissue samples, cerebrospinal fluid, or cellular models, aiding in the study of tau pathology mechanisms.

Clinically, S198 phosphorylation is explored as a potential biomarker for early AD diagnosis or monitoring disease progression. The antibody’s specificity for the phosphorylated epitope makes it valuable for immunohistochemistry, Western blotting, and ELISA-based assays. However, cross-reactivity with other phospho-epitopes or isoforms requires careful validation. Overall, Phospho-Tau(S198) antibodies are critical for advancing our understanding of tau dysfunction and developing targeted therapies for tau-related neurodegenerative disorders.