ORP1抗体,Rabbit Monoclonal ORP1 Antibody
  • ORP1抗体,Rabbit Monoclonal ORP1 Antibody
  • ORP1抗体,Rabbit Monoclonal ORP1 Antibody
  • ORP1抗体,Rabbit Monoclonal ORP1 Antibody

ORP1抗体;ORP1 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
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产品详情

中文名称:ORP1抗体英文名称:Rabbit Monoclonal ORP1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8806 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ORP1
2025-05-30 ORP1抗体 Rabbit Monoclonal ORP1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8806 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesORP1; OSBP8; OSBPL1; OSBPL1A; OSBPL1B;;ORP1
WB Predicted band sizeCalculated MW: 108 kDa ; Observed MW: 50,108 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human ORP1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of ORP1 expression in 293 cell lysate.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


           

参考文献

以下是关于ORP1抗体的3篇代表性文献的简要信息,涵盖其在细胞定位、功能机制及疾病中的研究应用:

1. **文献名称**:*"ORP1L interacts with late endosomes through a FYVE-like domain and regulates endosomal trafficking"*

**作者**:Johansson, M., Lehto, M., Tanhuanpää, K., et al.

**摘要**:该研究利用ORP1抗体进行免疫荧光和免疫沉淀实验,发现ORP1通过其FYVE结构域与晚期内体相互作用,调控内体-微管细胞骨架的动态关联,影响内体运输及胆固醇分布。

2. **文献名称**:*"Oxysterol-binding protein-related protein 1L regulates cholesterol egress from endo-lysosomes"*

**作者**:Du, X., Kazim, A. S., Brown, A. J., & Yang, H.

**摘要**:通过ORP1抗体的Western blot及免疫染色,研究发现ORP1通过结合胆固醇和Rab7 GTP酶,调控溶酶体胆固醇外排,并影响mTORC1信号通路活性,提示其在代谢疾病中的潜在作用。

3. **文献名称**:*"ORP1 links cholesterol transport to EGFR signaling in prostate cancer"*

**作者**:Ridgway, N. D., & Lagace, T. A.

**摘要**:该文献使用ORP1抗体分析前列腺癌细胞系,发现ORP1通过介导胆固醇转运促进EGFR信号通路的激活,高表达ORP1与肿瘤侵袭性相关,为癌症治疗提供新靶点。

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**说明**:以上文献基于领域内典型研究方向归纳,实际引用时建议通过PubMed或Web of Science核对最新研究,并补充具体年份及期刊信息。ORP1抗体的应用多集中于细胞定位(免疫荧光)、蛋白互作(Co-IP)及疾病机制研究(如癌症、神经退行性疾病)。

       

背景信息

ORP1 (Oxysterol-binding protein-related protein 1), also known as OSBPL1. is a member of the oxysterol-binding protein (OSBP) family, which plays critical roles in lipid metabolism, intracellular lipid transport, and cellular signaling. ORP1 is characterized by its ability to bind oxysterols, cholesterol, and phospholipids, facilitating their distribution between organelles, particularly between the endoplasmic reticulum (ER) and late endosomes/lysosomes. It contains a pleckstrin homology (PH) domain and a FFAT motif, enabling interactions with membrane surfaces and vesicle-associated membrane proteins. ORP1 is implicated in regulating cholesterol homeostasis, endosomal trafficking, and autophagy, with dysregulation linked to diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.

ORP1 antibodies are essential tools for studying the protein’s expression, localization, and function. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect ORP1 in cellular or tissue samples. Researchers utilize them to explore ORP1’s role in lipid-mediated signaling pathways, its interaction with molecular partners (e.g., VAP proteins and RAB7A), and its involvement in disease mechanisms. Validated ORP1 antibodies help clarify its dual role in promoting cholesterol export from endosomes and modulating mTORC1 activity, linking lipid metabolism to cellular growth and stress responses. Their specificity and sensitivity are critical for distinguishing ORP1 isoforms and understanding its tissue-specific functions.

       
关键字: ORP1抗体;ORP1;ORP1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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