Phospho-FRS2 (Tyr436)抗体;Phospho-FRS2 (Tyr436) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-FRS2 (Tyr436) in HUVEC lysates using Phospho-FRS2 (Tyr436) antibody.    

  
  

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     Immunohistochemistry analysis of paraffin-embedded Human brain tissue using FRS2 (Phospho-Tyr436) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.    

  
  

The Phospho-FRS2 (Tyr436) antibody is a specialized tool used to detect the phosphorylated form of FRS2 (Fibroblast Growth Factor Receptor Substrate 2) at tyrosine residue 436. FRS2 is a key adaptor protein involved in mediating signaling downstream of fibroblast growth factor receptors (FGFRs) and neurotrophic receptor tyrosine kinases. Upon receptor activation, FRS2 undergoes phosphorylation at specific tyrosine residues, including Tyr436. which serves as a docking site for downstream signaling molecules. This phosphorylation event is critical for propagating signals through the RAS-MAPK and PI3K-AKT pathways, regulating processes like cell proliferation, differentiation, and survival.

The Phospho-FRS2 (Tyr436) antibody is widely used in research to investigate FGFR signaling dynamics, particularly in studies related to cancer, developmental biology, and tissue homeostasis. Its specificity for the phosphorylated Tyr436 residue allows researchers to assess FRS2 activation status in response to growth factors, receptor mutations, or pharmacological inhibitors. Validation of this antibody typically includes Western blotting, immunofluorescence, or immunohistochemistry in cell lines or tissues with known FRS2 activation. Dysregulation of FRS2 phosphorylation has been implicated in various pathologies, including cancers with aberrant FGFR signaling, making this antibody a valuable tool for mechanistic and therapeutic studies. Proper controls, such as unstimulated samples or phosphatase-treated lysates, are essential to confirm antibody specificity.