Human TGF-Beta 1 / TGFB1 Protein, Tag Free
分子别名(Synonym)
CEDLAP,TGF-beta 1,TGFB1,DPD1,TGF-beta-1,TGFB
表达区间及表达系统(Source)
Human TGF-Beta 1 Protein, Tag Free (TG1-H4212) is expressed from human 293 cells (HEK293). It contains AA Ala 279 - Ser 390 (Accession # P01137-1).
Predicted N-terminus: Ala 279
蛋白结构(Molecular Characterization)

This protein carries no "tag".
The protein has a calculated MW of 12.8 kDa (monomer). The protein migrates as 14 kDa (monomer) under reducing (R) condition, and 25 kDa (Dimer) when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE).
内毒素(Endotoxin)
Less than 0.1 EU per μg by the LAL method / rFC method.
宿主蛋白残留(Host Cell Protein)
<0.5 ng/µg of protein tested by ELISA.
宿主核酸残留(Host Cell DNA)
<0.02 ng/μg of protein tested by qPCR.
无菌(Sterility)
Negative
支原体(Mycoplasma)
Negative.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in 0.085% TFA in 30% ACN with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution.


背景介绍
转化生长因子β1(TGFB1),亦称TGF-β1、CED、DPD1或TGFB,是转化生长因子β细胞因子超家族的多肽成员。该分泌蛋白具有多重细胞功能,包括调控细胞生长、增殖、分化和凋亡。TGFB1蛋白可调控细胞的生长与分裂(增殖)、细胞成熟执行特定功能的过程(分化)、细胞运动(迁移)及细胞自我毁灭程序(凋亡)。该蛋白广泛存在于人体各组织,在胚胎发育、血管形成、肌肉组织调节、体脂发育、伤口愈合及免疫系统功能中发挥关键作用。
TGFB1在构成骨骼的组织中尤为丰富,参与调节骨生长;同时大量存在于细胞间隙形成的复杂网络结构(细胞外基质)中。在细胞内,该蛋白通常处于关闭状态(失活),直至接收化学信号才被激活。TGFB1在免疫系统调控中具有重要作用,其对不同类型细胞或不同发育阶段的细胞呈现差异化活性。大多数免疫细胞(白细胞)均可分泌TGFB1。研究证实该蛋白可与TGFβ受体1、LTBP1、YWHAE、EIF3I及核心蛋白聚糖(Decorin)发生相互作用。
关键字: TGF-Beta 1;TGF-Beta 1蛋白;TGFB1重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。