Human Activin A / INHBA Protein, Tag Free
分子别名(Synonym)
Activin A,INHBA
表达区间及表达系统(Source)
Human Activin A Protein, Tag Free (ACA-H421b) is expressed from human 293 cells (HEK293). It contains AA Gly 311 - Ser 426 (Accession # AAH07858.1).
Predicted N-terminus: Gly 311
蛋白结构(Molecular Characterization)

This protein carries no "tag".
The protein has a calculated MW of 13.0 kDa. The protein migrates as 14-15 kDa under reducing (R) condition, and 23-25 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 0.1 EU per μg by the LAL method / rFC method.
无菌(Sterility)
Negative
支原体(Mycoplasma)
Negative.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in 0.056% TFA in 30% ACN with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.


背景介绍
激活素(Activin)与抑制素(inhibin)是两种密切相关的蛋白质复合物,但具有几乎完全相反的生物学效应。激活素可促进卵泡刺激素(FSH)的生物合成与分泌,并参与月经周期的调节。研究发现激活素还具有多种其他功能,包括在细胞增殖、分化、凋亡、代谢、稳态维持、免疫应答、伤口修复及内分泌功能中发挥作用。相反,抑制素则会下调FSH合成并抑制其分泌。
激活素是由不同β亚基(哺乳动物中包括βA、βB、βC和βE)形成的非糖基化同源二聚体或异源二聚体,而抑制素则是由独特的α亚基与某个β亚基组成的异源二聚体。激活素A是由两个βA链组成的广泛表达的同源二聚体:βA亚基还可与βB或βC亚基分别异源二聚化,形成激活素AB和激活素AC。14 kDa的成熟人源βA链与牛、猫、小鼠、猪及大鼠的βA链具有100%的氨基酸序列一致性。
关键字: Activin A;Activin A蛋白;Activin A重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。