产品概述
HDAC6 (3B2) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB
Human,Rat
产品性能
Unconjugated
Unmodified
IgG2a
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
HDAC6
HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6
10013
Q9UBN7
产品应用
WB: 1:500-1:1000
Calculated MW: 131 kDa; Observed MW: 160 kDa
研究背景
Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
研究领域
Epigenetics and Nuclear Signaling
武汉恩玑生命科技有限公司
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