产品概述
Ku70 (7B1) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB,ICC/IF,IP,ChIP
Human,Monkey
产品性能
Unconjugated
Unmodified
IgG1
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
XRCC6
XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-
2547
P12956
产品应用
WB: 1:500-1:1000 IF: 1:50-1:200 IP: 1:20 ChIP: 1:20
Calculated MW: 70 kDa; Observed MW: 67 kDa
研究背景
It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together.
研究领域
Epigenetics and Nuclear Signaling
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