产品概述
Lamin A/C (5D12) Mouse Monoclonal Antibody
Mouse Monoclonal Antibody
Mouse
WB,ICC/IF
Human,Mouse,Rat
产品性能
Unconjugated
Unmodified
IgG1
Monoclonal Antibody
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Affinity Purification
免疫原
LMNA
LMNA; LMN1; Prelamin-A/C
4000
P02545
产品应用
WB: 1:500-1:1000 IF: 1:50-1:200
Calculated MW: 74 kDa; Observed MW: 63,74 kDa
研究背景
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
研究领域
Tags & Cell Markers
武汉恩玑生命科技有限公司
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