产品概述
| 产品名称（Product Name） | AFP alpha 1 Fetoprotein(17C5)Mouse Monoclonal Antibody |
| 描述（Description） | Mouse Monoclonal Antibody |
| 宿主（Host） | Mouse |
| 应用（Application） | WB,IHC-P,IF-P,IF-F,ICC/IF |
| 种属反应性（Reactivity） | Human |
产品性能
| 偶联物（Conjugation） | Unconjugated |
| 修饰（Modification） | Unmodified |
| 同种型（Isotype） | IgG |
| 克隆（Clonality） | Monoclonal |
| 形式（Form） | Liquid |
| 存放说明（Storage） | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 储存溶液（Buffer） | PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol. |
| 纯化方式（Purification） | Affinity purification |
免疫原
| 基因名（Gene Name） | AFP |
| 别名（Alternative Names） | AFP; HPAFP; Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin |
| 基因ID（Gene ID） | 174 |
| 蛋白ID（SwissProt ID） | P02771 |
产品应用
| 稀释比（Dilution Ratio） | WB 1:2000, IF-P/IF-F/ICC/IF 1:200, IHC-P 1:50-300 |
| 蛋白分子量（Molecular Weight） | 70kDa |
研究背景
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008],developmental stage:Occurs in the plasma of fetuses more than 4 weeks old, reaches the highest levels during the 12th-16th week of gestation, and drops to trace amounts after birth. The serum level in adults is usually less than 40 ng/ml. AFP occurs also at high levels in the plasma and ascitic fluid of adults with hepatoma.,function:Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.,online information:Alpha-fetoprotein entry,PTM:Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.,PTM:Sulfated.,similarity:Belongs to the ALB/AFP/VDB family.,similarity:Contains 3 albumin domains.,subunit:Dimeric and trimeric forms have been found in addition to the monomeric form.,tissue specificity:Plasma. Synthesized by the fetal liver and yolk sac.,
研究领域
关键字： AFP;AFP;alpha;1;Fetoprotein(17C5)Mouse;Monoclonal;Antibody;一抗
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