产品概述
Phospho-ErbB2 (Y1139) (12W6) Rabbit Monoclonal Antibody
Rabbit Monoclonal Antibody
Rabbit
WB,IP
Human
产品性能
Unconjugated
Phospho Antibody
IgG
Monoclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Affinity purification
免疫原
ERBB2
CD340; CerbB2; ERBB2; HER2; Herstatin; MLN19; NEU; NGL; p185erbB2; TKR1;
2064
P04626
产品应用
WB 1:1000, IP 1:20-1:50
138kDa
研究背景
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
研究领域
武汉恩玑生命科技有限公司
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