产品概述
GDF15 (6F3) Rabbit Monoclonal Antibody
Rabbit Monoclonal Antibody
Rabbit
WB
Human
产品性能
Unconjugated
Unmodified
IgG
Monoclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Affinity purification
免疫原
GDF15
GDF-15; growth differentiation factor 15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB;
9518
Q99988
产品应用
WB 1:1000
34kDa
研究背景
Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL- expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).
研究领域
武汉恩玑生命科技有限公司
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