产品概述
PNK / PNKP (12Y10) Rabbit Monoclonal Antibody
Rabbit Monoclonal Antibody
Rabbit
WB,IHC-P,IP,IF-P
Human,Mouse
产品性能
Unconjugated
Unmodified
IgG
Monoclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Affinity purification
免疫原
PNKP
DEM1; EIEE10; MCSZ; PNK1; Pnkp;
11284
Q96T60
产品应用
WB 1:1000, IHC-P/IF-P 1:20, IP 1:20
57kDa
研究背景
Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Plays an important function in DNA repair following ionizing radiation or oxidative damage. Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785). Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193).
研究领域
武汉恩玑生命科技有限公司
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