产品概述
| 产品名称(Product Name) | Flk-1 (phospho Tyr1175) Rabbit Polyclonal Antibody |
| 描述(Description) | Rabbit Polyclonal Antibody |
| 宿主(Host) | Rabbit |
| 应用(Application) | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA |
| 种属反应性(Reactivity) | Human,Mouse,Rat |
产品性能
| 偶联物(Conjugation) | Unconjugated |
| 修饰(Modification) | Phospho Antibody |
| 同种型(Isotype) | IgG |
| 克隆(Clonality) | Polyclonal |
| 形式(Form) | Liquid |
| 存放说明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 储存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N. |
| 纯化方式(Purification) | Affinity purification |
免疫原
| 基因名(Gene Name) | KDR |
| 别名(Alternative Names) | KDR; FLK1; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD antigen CD309 |
| 基因ID(Gene ID) | 3791 |
| 蛋白ID(SwissProt ID) | P35968 |
产品应用
| 稀释比(Dilution Ratio) | WB 1:500-1:2000, IHC-P 1:100-1:300, ELISA 1:10000, IF-P/IF-F/ICC/IF 1:50-200 |
| 蛋白分子量(Molecular Weight) | 152kDa |
研究背景
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009],catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with MYOF (By similarity). Interacts with SHB; upon VEGF activation. Interacts with HIV-1 Tat.,
研究领域
Cytokine-cytokine receptor interaction;Endocytosis;VEGF;Focal adhesion;
关键字: KDR;Flk-1;(phospho;Tyr1175);Rabbit;Polyclonal;Antibody;一抗
武汉恩玑生命科技有限公司(EnkiLife)是一家深耕生命科学,专注细胞生物学和免疫学科研试剂的研发、生产与销售的生物技术企业,在全球100多个国家和地区开展业务,致力于为科研工作者提供高质量的产品和卓越的客户服务,推动生命科学的发展。
EnkiLife的产品线涵盖细胞系、原代细胞、细胞培养基、血清、细胞检测试剂盒、重组靶点蛋白、细胞因子、重组抗体、ELISA试剂盒、生化试剂盒等,并提供技术服务与定制开发,覆盖了生命科学研究的各大关键领域,包括细胞生物学、癌症、免疫学、神经科学、心血管疾病、干细胞、表观遗传学、内分泌、蛋白质组学、代谢组学等,全方位满足您的实验需求,让您享受科研的乐趣!
公司现已建立四大技术平台:
EnCyto?细胞培养及检测平台:拥有细胞系库(500+)、原代细胞库(500+)、基础培养基和完全培养基(1200+)
EnkiPro?重组蛋白平台:现货产品2000+,可提供定制化表达服务
EnAb?重组抗体平台:重组兔单抗(3000+),可提供定制化和标记服务
EnKits?试剂盒开发平台:可提供优质的ELISA试剂盒、配套试剂、抗体对、生化试剂盒等相关产品
EnkiLife在生产管理方面引入ISO9001质量管理体系和信息化、自动化的管理工具,拥有高效稳定的交付能力,与全球知名品牌建立了紧密的合作。
EnkiLife始终坚持以技术创新为驱动,以匠心铸就品质,以品质服务客户。
我们期待与更多的全球科研工作者和企业携手合作,共同推动生命科学领域的进步与发展。