产品概述
LRBA Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
IHC-P,IF-P,IF-F,ICC/IF
Human,Mouse
产品性能
Unconjugated
Unmodified
IgG
Polyclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Affinity purification
免疫原
LRBA BGL CDC4L LBA
987
P50851
产品应用
IHC-P 1:50-300, IF-P/IF-F/ICC/IF 1:50-200
314kDa
研究背景
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],caution:Was originally (PubMed:1505956) said to be similar to yeast CDC4, but that similarity is very limited.,induction:By lipopolysaccharide (LPS).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 BEACH domain.,similarity:Contains 6 WD repeats.,
研究领域
武汉恩玑生命科技有限公司
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