产品概述
NUMB Rabbit Polyclonal Antibody
Rabbit Polyclonal Antibody
Rabbit
WB,IF-P,IF-F,ICC/IF,ELISA
Human,Mouse,Rat
产品性能
Unconjugated
Unmodified
IgG
Polyclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Affinity purification
免疫原
NUMB
NUMB; Protein numb homolog; h-Numb; Protein S171
8650
P49757
产品应用
WB 1:500-2000, IF-P/IF-F/ICC/IF/ICC 1:100-500, ELISA 1:5000-20000
70kDa
研究背景
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],function:Implicated in the control of cell fate decisions during development.,PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,sequence caution:Intron retention.,similarity:Contains 1 PID domain.,subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.,
研究领域
Notch;
武汉恩玑生命科技有限公司
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