NanoActive RAL （RETINAL，Retinaldehyde）是浦瑞生物基于 NanoActive 纳米递送平台开发的纳米包裹视黄醛（Retinal）原料，用于高效且相对温和的抗老与修护护肤配方。视黄醛作为维生素 A 家族中活性更接近视黄酸的一员，兼具优异的抗皱抗老能力与较好的耐受性，但本身极易受光、氧和温度影响而分解，也容易引起刺激。
通过脂质纳米载体包裹，NanoActive RAL 可将视黄醛稳定分散于水相体系中，大幅提高其在生产、储存及使用过程中的稳定性，并通过纳米粒径实现更均匀的角质层渗透与缓释释放，从而在保障功效的同时显著降低刺激风险，提升敏感肌和“入门级”人群的使用舒适度。
优势亮点：
速度更快： 相比需要两步体内代谢才能转化为视黄酸的视黄醇，视黄醛仅需一步转化，有文献和品牌公开资料声称其转化速度可达视黄醇的约 11 倍，具备更高的生物利用度潜力。
功效双重： 在传统抗衰老、促进胶原生成、细纹淡化的基础上，视黄醛本身还对痤疮丙酸杆菌（C. acnes）具有直接抑菌作用，兼顾抗老与抗痘两大需求。
临床验证： 公开临床研究显示，视黄醛配方在减少皱纹方面的效果可与 0.05% 视黄酸达到“非劣效性”水平，同时耐受性更佳，为高功效与低刺激兼顾的抗老方案提供有力支持。
NanoActive RAL is a nano-encapsulated retinal (retinaldehyde) active developed on PuriPharm's NanoActive delivery platform for high-performance yet well-tolerated anti-ageing and skin-repair formulations. Retinal is a vitamin A derivative whose biological activity is closer to retinoic acid than retinol, offering strong anti-wrinkle and skin-renewal benefits while generally providing better tolerability. However, free retinal is highly sensitive to light, oxygen and heat, and can still cause irritation in conventional formulations.
By encapsulating retinal in lipid-based nanocarriers that are finely dispersed in the aqueous phase, NanoActive RAL markedly improves the chemical and photostability of retinal during manufacturing, storage and consumer use. The nano-sized particles support more homogeneous penetration into the stratum corneum and a controlled-release profile, helping to maintain efficacy while reducing peak exposure on the skin surface and minimizing irritation, which is especially valuable for first-time vitamin A users and more delicate skin types.
Key advantages:
Faster pathway: Unlike retinol, which requires two metabolic steps to be converted into retinoic acid, retinal needs only one. Published data and brand communications report that retinal can achieve up to ~11-fold faster conversion than retinol, implying higher bioavailability potential. NanoActive RAL is designed to leverage this intrinsic advantage of retinal.
Dual benefit: Retinal not only delivers clinically relevant anti-ageing effects (collagen stimulation, wrinkle reduction, texture refinement) but also shows direct bacteriostatic activity against Cutibacterium acnes (C. acnes), enabling simultaneous anti-ageing and anti-acne positioning.
Clinically validated: Clinical studies on retinal-based formulations have demonstrated wrinkle-reduction efficacy that is non-inferior to 0.05% tretinoin, while typically offering a more favorable tolerability profile—supporting NanoActive RAL as a next-generation retinal solution combining potency, stability and comfort.
关键字： 全反式视黄醛;脂质体;纳米包裹;
浦瑞生物医药秉持质量源于设计（QbD）的理念，以安全、有效、稳定为产品开发金标准，综合运用现代生物技术、东方传统医药智慧、纳米传输等新型制剂技术，开发了系列生物活性物原料，可以为医疗健康产业领域客户提供荣格技术创新奖专利产品--全球首创纳米AA酯（超A、视黄醇视黄酸酯）、纳米包裹HPR（超A、羟基频哪酮视黄酸酯）、玻色因（璞瑞因）、EUK-134、麦角硫因、依克多因、富勒烯、锁水磁石、纳米包裹虾青素、纳米艾地苯醌、超分子水杨酸、壬二酸凝胶、纳肤丽（即时祛皱）、医肤敏（及时镇痛止痒抗敏）纳米包裹大麻二酚、燕麦生物碱、己脒定二羟乙基磺酸盐、纳米包裹视黄醛、纳米包裹白藜芦醇、纳米包裹复合维生素（祛眼袋、祛黑眼圈）、季铵盐-73（皮傲宁）、眼肤丽、纳米包裹神经酰胺、生物糖胶、酵母葡聚糖、甘油葡糖苷、水溶性纳米硫磺、纳米硫辛酸、纳米辅酶Q10、维生素C脂质体、谷胱甘肽脂质体、褪黑素脂质体、叶黄素脂质体、藏红花酸、藏红花酸钠、水解角蛋白、链激酶、阿那白滞素（IL-1ra）、白转黑（乌发）、葡糖基芦丁、槲皮素脂质体、水溶性芦丁、栀子苷、丹酚酸、芹菜素、羟基酪醇脂质体、大豆异黄酮脂质体、水溶性伞花烃、阿魏酸脂质体、咖啡酸脂质体、视黄醇脂质体、丁基间苯二酚脂质体、己基间苯二酚脂质体、377脂质体、紫檀芪脂质体、四氢姜黄素脂质体、姜黄素脂质体、二裂酵母、Pitera(半乳糖酵母)、合生元微生态纳米乳。