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Adiponectin/Acrp30 蛋白
品牌:MedChemExpress (MCE)
货号:HY-P70504
纯度:Greater than 95% as determined by reducing SDS-PAGE.
运输条件:美国大陆的室温;其他地方可能有所不同。
产品活性:Adiponectin/Acrp30 蛋白, Human (HEK293, His)可提高细胞对胰岛素的敏感性,也可作为治疗糖尿病性肌腱病的潜在蛋白。
生物活性:通过其抑制大鼠肝细胞产生葡萄糖的能力来衡量。该作用的 ED50 为 5.936 µg/mL,对应的比活性为 168.46 单位/mg。
研究背景:重组人脂联素可用于受损动脉并减轻血管炎症反应。据报道,生理浓度的重组人脂联素可抑制肿瘤坏死因子-α (TNF-α) 诱导的内皮粘附分子表达、巨噬细胞向泡沫细胞的转化以及巨噬细胞中 TNF-α 的表达[1]。重组人脂联素可作为治疗糖尿病肌腱病的潜在蛋白质,在体外促进肌腱细胞祖细胞增殖和肌腱分化[2]。
种属:Human
蛋白编号:Q15848 (E19-N244)
基因 ID:9370
同用名:Adiponectin; 30 kDa Adipocyte Complement-Related Protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte; C1q and Collagen Domain-Containing Protein; Adipose Most Abundant Gene Transcript 1 Protein; apM-1; Gelatin-Binding Protein; ADIPOQ; ACDC; ACRP3
详情参考:http://www.medchemexpress.cn/cytokines/adiponectin-acrp30-protein-human-hek293-his.html
参考文献:
[1]. Kumada M, et al. Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation. 2004 May 4;109(17):2046-9.
[2]. Rothan HA, et al. Recombinant human adiponectin as a potential protein for treating diabetic tendinopathy promotes tenocyte progenitor cells proliferation and tenogenic differentiation in vitro. Int J Med Sci. 2013 Nov 27;10(13):1899-906.