(Nezutatug)Biosimilar Reference Antibody-GS40472

货号：GS40472

Nezutatug is a human IgG1‑kappa monoclonal antibody that specifically targets human epidermal growth factor receptor 3 (HER3, also known as ErbB3), a member of the EGFR/ErbB receptor tyrosine kinase family. By binding to HER3, nezutatug blocks the interaction between HER3 and its ligand neuregulin (NRG), thereby inhibiting downstream oncogenic signaling pathways (e.g., PI3K/AKT) that drive tumor cell proliferation and survival.