(Belrestotug)Biosimilar Reference Antibody-GS40069 新品

货号：GS40069

Belrestotug (also known as EOS-448) is a fully human monoclonal antibody of the IgG1 kappa isotype designed as an immune checkpoint inhibitor. It functions by specifically targeting and blocking the T-cell Immunoreceptor with Ig and ITIM domains (TIGIT). This dual-action mechanism not only blocks TIGIT's direct inhibitory signal on T and NK cells but also enhances the co-stimulatory signaling through the CD226 pathway. Furthermore, its IgG1 isotype suggests it may contribute to the depletion of high-TIGIT expressing immunosuppressive regulatory T cells (Tregs) via Antibody-Dependent Cellular Cytotoxicity (ADCC). It has been investigated in combination with PD-1 inhibitors for various advanced solid tumors.