Dexamethasone acetate

[Product name]: Dexamethasone acetate
[Chemical name]: 9-fluoro-11β，17-dihydroxy-l6α-methyl-3,20-dioxopregna-1,4-dien-2l-yl acetate
[Product category]：corticosteroids
[CAS NO.] 1177-87-3
[molecular formula]: C24H31FO6
[molecular weight]: 434.5
[Packing specification]: 1KG/tin 
[specification]: CP/EP/USP/BP 
[Appearance]: white or almost white crystalline powder, odorless, tasted bitter  
[Identification]: it should be positive 
[Melting point]: 223℃~233℃
[specific rotation]: +82°~+88°
[related substance]: max impurity ≤0.5%, total impurities≤1.0%
[loss on drying]: ≤0.5%
[residue on ignition]: ≤0.1%
[selenium value]: ≤0.005%
[absorptive index]: 343~371
[assay]: calculated the content of C24H31FO6 97on the dried basis, it should be 97.0%~102.0%
[storage]: store in a airtight container, protected from light. 
[decription]:
Dexamethasone Acetate is a glucocorticoid with anti-inflammatory properties. One possible 
mode of action of the anti-inflammatory properties has been documented by Dexamethasone 
Acetate inhibitiing upregulation of ICAM-1 (intercellular adhesion molecule-1) in cultured
 human mast cells. The compound also displays anti mitotic activity against chemically 
transformed mouse fibroblasts by halting mitosis from entering the S-phase. Dexamethasone 
Acetate has also been determined to markedly decrease the number of activated macrophages. 
In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels 
of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice.