(Rocatinlimab)Biosimilar Reference Antibody-GS40616

货号：GS40616

Rocatinlimab (AMG 451/KHK4083) is a fully human IgG1 monoclonal antibody that acts as an OX40 antagonist. It targets and blocks OX40 (CD134), a co-stimulatory receptor on activated T cells. By inhibiting OX40-OX40L interaction, it reduces the activation, proliferation, and survival of pathogenic T cells, thereby dampening the immune response. It is specifically developed for the treatment of moderate-to-severe atopic dermatitis, aiming to reduce skin inflammation and pruritus.