Human Legumain Protein, His Tag (Pro-form)
分子别名(Synonym)
Legumain
表达区间及表达系统(Source)
Human Legumain Protein, His Tag (LEN-H52H3) is expressed from human 293 cells (HEK293). It contains AA Val 18 - Tyr 433 (Accession # Q99538-1).
Predicted N-terminus: Val 18
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 49.5 kDa. The protein migrates as 55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method / rFC method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Supplied as 0.2 μm filtered solution in 20 mM Tris, 50 mM NaCl, PH7.5 with glycerol as protectant.
Contact us for customized product form or formulation.
运输(Shipping)
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存储(Storage)
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 3 months under sterile conditions.
背景介绍
该基因编码半胱氨酸肽酶家族C13的一名成员,在内体/溶酶体降解系统中发挥重要作用。所编码的无活性前体蛋白通过自催化方式切除C端抑制性前肽,生成具有活性的内肽酶,该酶在天冬酰胺残基的C端侧切割蛋白质底物。缺乏该编码蛋白的小鼠在溶酶体蛋白质加工过程中存在缺陷,导致蛋白质在溶酶体中积聚,并出现类似噬血细胞性淋巴组织细胞增生症的症状。
关键字: Legumain;Legumain蛋白;Legumain重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。