Human GPR75 Full Length Protein, Flag,His Tag (Detergent)
分子别名（Synonym）
GPRchr2, WI31133
表达区间及表达系统（Source）
Human GPR75 Full Length Protein, Flag,His Tag (GP5-H52D3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Val 540 (Accession # O95800).
Predicted N-terminus: Asp
蛋白结构（Molecular Characterization）
This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 78.4 kDa.
内毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method / rFC method.
纯度（Purity）
>90% as determined by SDS-PAGE.
制剂（Formulation）
This product is not suitable for cell based experiments due to cytotoxicity of DDM.
DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumstances should you remove DDM and CHS.
DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.
If glycerol is not compatible with your application, remove glycerol just before the immediate experiment, and NEVER store glycerol-free protein solution.
Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.
Contact us for customized product form or formulation.
运输（Shipping）
This product is supplied and shipped with dry ice, please inquire the shipping cost.
存储（Storage）
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The product MUST be stored at -70°C or lower upon receipt;
-70°C for 3 months under sterile conditions.
背景介绍
该受体是由趋化因子CCL5/RANTES激活的G蛋白偶联受体。它可能与异源三聚体Gq蛋白偶联，在激活后刺激三磷酸肌醇的产生和钙离子的动员。该受体与CCL5/RANTES协同作用，可能通过激活涉及PI3激酶、Akt激酶和MAP激酶的下游信号通路，在神经元存活中发挥作用。CCL5/RANTES还可能通过激活该受体来调节胰岛细胞的胰岛素分泌。
关键字： GPR75;GPR75蛋白;GPR75重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group（股票代码：301080）是成立于2010年的跨国生物科技公司，是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球，横跨亚洲、北美洲、欧洲，在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家，与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。