EHMT2/G9A 重组兔单克隆抗体 (S-4200)-S0B6612

EHMT2 (also called G9a) is a nuclear lysine methyltransferase that chiefly di-methylates histone H3 at lysine 9 (H3K9me2) and lysine 27 (H3K27me1/2) to establish facultative heterochromatin and transcriptionally silence target genes, and it can act either as a repressor or, through auto-methylation-dependent recruitment of cofactors such as HP1γ and p300, as a co-activator of transcription; the enzyme exists as a homodimer or heterodimer with the related GLP/EHMT1, contains an N-terminal ankyrin-repeat domain for chromatin docking and a catalytic SET domain for methyl transfer, and its dysregulation—via overexpression in diverse solid and hematologic cancers or down-regulation in addiction and neuropathic pain—alters the expression of hundreds of genes by both histone and non-histone methylation, thereby controlling embryonic development, stem-cell lineage commitment, immune-cell differentiation, synaptic remodeling, and tumorigenicity .