Synaptopodin 重组兔单克隆抗体 (SDT-3331-4)-S0B2458

Synaptopodin is an actin-associated protein concentrated in ~30 % of large dendritic spines of telencephalic neurons where it nucleates the spine apparatus—stacks of smooth endoplasmic reticulum that function as local calcium stores and sites of protein synthesis—thereby enabling PKA- and activity-dependent enlargement of spine heads, trafficking of GluA1-containing AMPA receptors, and the expression of long-term potentiation and memory formation, so that synaptopodin-deficient mice lack spine apparatuses, show blunted LTP, and exhibit impaired spatial learning.