髓鞘蛋白零 重组兔单克隆抗体 (SDT-1225-8)-S0B2407

Myelin protein zero (P0, MPZ) is a 28–30 kDa type I transmembrane glycoprotein that constitutes 50–70 % of total protein in peripheral nervous system (PNS) compact myelin, where it is expressed continuously by myelinating Schwann cells until mature myelin is formed; its extracellular immunoglobulin-like domain mediates homophilic adhesion between apposing membrane pairs to generate the characteristic intraperiod line, while its short cytoplasmic tail cooperates with myelin basic protein to zipper the cytoplasmic faces, enabling the tight membrane stacking that gives PNS myelin its insulating properties, and mutations in the MPZ gene underlie a spectrum of incurable demyelinating peripheral neuropathies such as Charcot–Marie–Tooth disease by disrupting these adhesive and structural functions.