Pacific Blue 小鼠抗大鼠 CD47 抗体 (OX-101)-S0B80240

CD47 is a ubiquitously expressed transmembrane glycoprotein that serves as a critical “don’t-eat-me” signal by engaging signal-regulatory protein α (SIRPα) on macrophages and dendritic cells, thereby inhibiting phagocytosis and bridging innate and adaptive immunity; beyond immune evasion, CD47 modulates integrin activation, cell adhesion, migration, apoptosis, and metabolic signaling, and its marked over-expression on diverse tumor cells—driven by oncogenic pathways such as KRAS-PI3K-STAT3, hypoxia-HIF-1α, or amino-acid-mTOR cascades—correlates with reduced patient survival, making blockade of the CD47–SIRPα axis a promising therapeutic strategy to restore anti-tumor immunity.