Alexa Fluor? 647 小鼠抗小鼠 XCR1 抗体 (S-R601)-S0B8483

XCR1 is a conserved, 37-kDa, seven-transmembrane, G-protein-coupled receptor selectively expressed on CD8α⁺ and CD103⁺ conventional dendritic cells; its only ligand, XCL1, is secreted by activated CD8⁺ T and NK cells to form a feed-forward loop that efficiently recruits antigen-bearing dendritic cells into draining lymph nodes, licenses cross-presentation, and amplifies cytotoxic immune responses against viruses and tumors, while genetic or antibody blockade of XCR1 impairs viral clearance, vaccine efficacy, and checkpoint-blockade-mediated anti-tumor immunity.