奥昔布宁-abs816335

一、产品概述

二、产品信息

多重荧光免疫组化染色是基于抗原、抗体特异性结合的原理，选用辣根过氧化物酶（HRP）标记的二抗抗体，对试剂盒中的荧光染料进行活化，将信号共价结合到抗原上。借助于不同的荧光染料标记，通过多轮染色循环实现组织或细胞的原位多靶点染色。

Oxybutynin N-deethylation in human liver microsomes in vitro is potently inhibited by ketoconazole (IC50 4.5 mM), less and variably by itraconazole and not by quinidine or several other reference inhibitors, suggesting that CYP3A enzymes are predominant catalysts of the reaction. Oxybutynin inhibits CYP3A4- and CYP2D6- associated activities (testosterone 6 beta-hydroxylase and dextromethorphan O- demethylase, respectively) in human liver microsomes. Oxybutynin is predominantly metabolized by CYP3A4 and CYP3A5 but not by CYP2D6. Oxybutynin (30, 100 nM) competitively antagonizes acetylcholine-induced contractions but does not alter those induced by histamine. Oxybutynin (up to 10 mM) induces a non-competitive depression of responses to both agonists and causes a parallel shift to the right of the Ca2+-induced contractions in taenia caeci strips bathed in a Ca2+-free, high-K+ medium. Oxybutynin (1-10 mM) impairs rhythmic muscular contractions in normal medium and after CaCl2 addition in Ca2+-free medium. Oxybutynin increases the perfusion pressure starting at 100 mM in perfused rat liver. Oxybutynin also increases the perfusion pressure in the hepatic artery.

Oxybutynin decreases significantly binding potential (BP) of (+)N-methyl-3-piperidyl benzilate ((+)3-MPB) in the rat cerebral cortex and corpus striatum in a dose-dependent manner. Oxybutynin induces a significant decrease in micturition pressure without changes in BVC in obstructed rats.

三、背景

四、制备和贮存

五、产品特点

六、注意事项