HaloAUTAC tt15 (also known as Halo PROTAC 1 ) is a synthetic small-molecule autophagy-targeting chimera (AUTAC) designed for targeted degradation of HaloTag-carrying proteins . The compound contains a HaloTag-reactive chloroalkyl moiety, an AUTAC functional region, and a flexible polyether linker that connects the two functional components.
HaloAUTAC tt15 promotes degradation of HaloTag-fused target proteins through an autophagy/lysosomal degradation pathway , providing an alternative to conventional PROTACs that primarily utilize the ubiquitin–proteasome system. In cell-based research, HaloAUTAC tt15 has been reported to induce degradation of EGFP-HaloTag fusion protein in HeLa cells.
CAS No.: 2241668-45-9
Molecular Formula: C₃₃H₄₉Cl₂N₇O₈S
Molecular Weight: 774.76 g/mol
Product Type: Autophagy-targeting chimera (AUTAC) / Targeted Protein Degradation (TPD) compound
Target: HaloTag fusion proteins
Degradation Pathway: Autophagy–lysosome pathway
HaloAUTAC tt15 is useful as a chemical biology research tool for studying targeted autophagic protein degradation, HaloTag-based protein regulation induced proximity, autophagy, lysosomal degradation, and targeted protein degradation . Its modular linker-containing structure also provides a useful reference for the design and synthesis of AUTAC degraders and functional degrader conjugates .
关键字： AUTAC;lysosome;autophagy pathway;PEG linker;
杭州埃米尔生物技术有限公司位于浙江省杭州市钱塘区下沙街道安和药谷，立足杭州生物医药产业集聚区位优势，专注深耕ADC/XDC 生物偶联技术研发服务、医药小分子中间体定制合成两大核心业务，是聚焦抗体偶联药物上下游研发配套的专业化生物技术初创企业，面向药企、CRO 公司、高校科研院所提供从工艺开发、样品合成到质控分析的一站式技术外包解决方案。