PDEδ autophagic degrader 1 (CAS No. 3054112-59-0) is a synthetic autophagosome-tethering compound (ATTEC) designed to induce the selective degradation of PDEδ (phosphodiesterase δ) through the autophagy–lysosome pathway. The molecule contains a PDEδ-targeting ligand, a linker region, and an LC3-binding component , enabling recruitment of the target protein to autophagosomes for subsequent lysosomal degradation.
This small-molecule degrader is useful for studying PDEδ degradation, autophagy-mediated protein clearance, KRAS-related signaling, targeted protein degradation, and chemical biology .
CAS No.: 3054112-59-0
Molecular Formula: C₄₁H₄₂Br₂IN₇O₅
Molecular Weight: 999.53 g/mol
Product Type: ATTEC / autophagic protein degrader
Target: PDEδ
Degradation Pathway: Autophagy–lysosome pathway
Applications: Targeted protein degradation, autophagy research, PDEδ research, KRAS-related cancer research, and chemical biology.
关键字： ATTEC;PDEδ ligand;PDE delta;autophagy degrader;
杭州埃米尔生物技术有限公司位于浙江省杭州市钱塘区下沙街道安和药谷，立足杭州生物医药产业集聚区位优势，专注深耕ADC/XDC 生物偶联技术研发服务、医药小分子中间体定制合成两大核心业务，是聚焦抗体偶联药物上下游研发配套的专业化生物技术初创企业，面向药企、CRO 公司、高校科研院所提供从工艺开发、样品合成到质控分析的一站式技术外包解决方案。