Mezigdomide (CC-92480) is a cereblon (CRBN) E3 ubiquitin ligase modulating agent (CELMoD) and molecular glue degrader. It binds to cereblon and modulates CRBN-mediated protein degradation, making it a useful research compound for investigating targeted protein degradation (TPD), molecular glue mechanisms, and cereblon biology . Mezigdomide has demonstrated potent antimyeloma activity and is widely used in research related to multiple myeloma and CRBN-mediated protein degradation.
CAS No.: 2259648-80-9
Formula: C₃₂H₃₀FN₅O₄
Molecular Weight: 567.61 g/mol
Category: Targeted Protein Degradation (TPD) → Molecular Glues / CELMoDs → Cereblon Modulators
For research use only. Not for human or clinical use.
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