中文名称:
克唑替尼
中文别名:
克里唑替尼;
克里唑啼尼;
3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺;
3-[(R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(哌啶-4-基)-1H-吡唑-4-基]吡啶-2-胺;
英文名称:
Crizotinib
英文别名:
(R)-Crizotinib;
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine;
Xalkori;
CAS号:
877399-52-5
分子式:
C21H22Cl2FN5O
分子量:
450.33700
精确质量:
449.11900
PSA:
77.99000
LogP:
5.94770
Crizotinib (trade name Xalkori, Pfizer) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children
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